Authors:Armas López Leonel, Piña-Sánchez Patricia, Arrieta Oscar, Guzman de Alba Enrique, Ortiz Quintero Blanca, Santillán Doherty Patricio, Christiani David C., Zúñiga Joaquín and Ávila-Moreno Federico Abstracts: Several homeobox-related gene (HOX) transcription factors such as mesenchyme HOX-2 (MEOX2) have previously been associated with cancer drug resistance, malignant progression and/or clinical prognostic responses in lung cancer patients; however, the mechanisms involved in these responses have yet to be elucidated. Here, an epigenomic strategy was implemented to identify novel MEOX2 gene promoter transcription targets and propose a new molecular mechanism underlying lung cancer drug resistance and poor clinical prognosis. Chromatin immunoprecipitation (ChIP) assays derived from non-small cell lung carcinomas (NSCLC) hybridized on gene promoter tiling arrays and bioinformatics analyses were performed, and quantitative,…